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Tocainide是一种副作用小、有效半衰期长的口服抗心律失常药物。本文报道用狗作体内及离体实验,以估计此药的电生理特性。体内实验:24只狗在疏苯妥钠或α-chloralase静脉麻醉下,用右房起搏引致房性过早除极,或利用哇巴因毒性反应及阻断冠状动脉前降支引致室性心动过速,或于右室表面用双极电极刺激以测定心室
Tocainide is a small anti-arrhythmic drug with low side effects and long half-life. This article reports the use of dogs as in vivo and in vitro experiments to evaluate the electrophysiological properties of this drug. In vivo experiments: Twenty-four dogs under ventricular anesthesia with spironolactone or alpha-chloralase, premature atrial depolarization with right atrial pacing or ventricular arrhythmia with ouabain toxicity and occlusion of the anterior descending coronary artery Tachycardia, or bipolar stimulation of the right ventricular surface to determine ventricular