利什曼原虫感染后引起复杂的免疫应答,细胞因子作为介质在其中起关键作用。同一种细胞因子在不同的利什曼原虫感染中有不同的变化,同一种利什曼原虫感染不同遗传背景种系小鼠会刺激产生不同的细胞因子,部分以往被认为是促进利什曼原虫感染发展的细胞因子在最近的研究中又有了新发现,本文综述了近年来发现的IFN-γ、TNF-α、GM-CSFI、L-1αI、L-12I、L-18和IL-4等细胞因子在利什曼原虫感染中的作用。 Leishmania infection causes a complex immune response in which cytokines play a key role. The same cytokines in different Leishmania infections have different changes, the same Leishmania infection in different genetic backgrounds of germline mice will stimulate the production of different cytokines, some previously considered to be Leishmania In recent years, there have been new discoveries about the cytokines in the development of infectious diseases. This review summarizes the recent discovery of IFN-γ, TNF-α, GM-CSFI, L-1αI, L-12I, L-18 and IL-4 The Role of Cytokines in Leishmania Infection.