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目的探讨心肌做功指数(myocardial performance index,MPI 又称 Tei index)在评价蒽环类药物(an-thracycline,ATC)对肿瘤患者左心功能早期损害方面的临床应用价值。方法测定并比较50例肿瘤患者 ATC 化疗前和化疗后6个月常规超声心动图参数及 Tei 指数的变化。结果与化疗前相比,左心室等容舒张时间(IRT)延长(P<0.05),左心室 Tei 指数明显升高(P<0.01)。而左心内径及收缩功能指标(EF、FS)化疗前后无显著性差异,仅14例(28%)患者化疗后出现一项或多项常规左室舒张功能指标异常(E 峰减低,A 峰升高,E/A<1)。结论 Tei 指数能更早、更敏感地评价 ATC 对肿瘤患者左心功能的损害。
Objective To investigate the clinical value of myocardial performance index (MPI), which is also called Tei index, in evaluating the early damage of left ventricular function in patients with an-thracycline (ATC). Methods The changes of routine echocardiographic parameters and Tei index of 50 patients with cancer before and after 6 months of chemotherapy were measured and compared. Results Compared with those before chemotherapy, left ventricular isovolumetric relaxation time (IRT) was prolonged (P <0.05) and left ventricular Tei index was significantly increased (P <0.01). There were no significant differences in left ventricular diameter and systolic function (EF, FS) before and after chemotherapy. Only 14 patients (28%) had one or more abnormal left ventricular diastolic dysfunction after chemotherapy (E peak decreased, peak A Rise, E / A <1). Conclusion The Tei index can assess the damage of left ventricular function in cancer patients earlier and more sensitively.