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目前临床上对于进展期胃癌缺乏有效的治疗手段,其手术根治率低、预后差。2007年MAGIC实验首先提出新辅助化疗能有效提高进展期胃癌患者术后生存率,此后多项临床研究证实新辅助化疗可在术前降低肿瘤分期,提高进展期胃癌根治性切除率和术后生存时间,但对于其实际临床应用目前尚无统一标准。在此对进展期胃癌新辅助化疗的临床应用、疗效等问题作简要综述。
At present, there is a lack of effective treatment for advanced gastric cancer clinically, and its operation has a low cure rate and a poor prognosis. 2007 MAGIC experiment first proposed neoadjuvant chemotherapy can effectively improve the survival rate of patients with advanced gastric cancer after a number of clinical studies have confirmed that neoadjuvant chemotherapy can reduce the tumor staging before surgery to improve the radical resection of gastric cancer and postoperative survival Time, but there is no uniform standard for its actual clinical application. Here for the clinical application of neoadjuvant chemotherapy for advanced gastric cancer, efficacy and other issues briefly reviewed.