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[目的]了解成都地区健康人群流行性脑脊髓膜炎(流脑)带菌状况,为分析发病趋势提供依据。[方法]2007年5月监测4个区(市)县,用随机抽样法抽取5个不同年龄组健康人群咽拭子于卵黄双抗琼脂培养基进行脑膜炎奈瑟氏菌分离培养及实时荧光PCR分离。[结果]共采集标本999份,培养法阳性率1.1%(11/999);菌株分别为A群2株(19%),B群4株(36%),C群5株(45%),人群带菌以C群和B群为主;4个地区中青羊区带菌率最高(2.8%)。男性带菌率1.3%,女性0.9%,男女类似;不同年龄组菌群阳性率类似。PCR法检出率8.4%(84/999),高于培养法(X2=58.90,P<0.01)。[结论]成都市健康人群流脑带菌率较低,但要警惕C群和B群流脑菌群引起的流行。
[Objective] To understand the prevalence of epidemic cerebrospinal meningitis (MC) in healthy population in Chengdu and provide basis for analyzing the trend of the disease. [Methods] In May 2007, 4 counties (cities) counties were monitored. Randomly sampling 5 throat swabs from healthy people of different age groups were used to isolate and culture Neisseria meningitidis in real-time fluorescence PCR separation. [Results] A total of 999 samples were collected and the positive rate was 1.1% (11/999) by culture method. The strains were 2 strains of A group (19%), 4 strains of B group (36%) and 5 strains of C group (45% , And the population was mainly C group and B group; the highest rate of bacteria was found in Zhongqingyang area (2.8%) in four districts. Men carrying rate of 1.3%, 0.9% of women, similar to men and women; similar positive rates of flora in different age groups. PCR detection rate of 8.4% (84/999), higher than the culture method (X2 = 58.90, P <0.01). [Conclusion] The prevalence of meningitis in healthy population in Chengdu is relatively low, but vigilance should be paid to the epidemic caused by meningococcal group C and B.