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作者在20例 DNA 多聚酶和 HBeAg 阳性的慢性乙型肝炎患者中,研究了大剂量重组白细胞 A 干扰素(γIFN-αA)的耐受性、药物动力学和抗病毒效果。患者男19例,女1例;年龄19～47岁,平均30.4岁;肝组织学诊断为慢性迁延性肝炎11例,慢性活动性肝炎7例,肝硬变2例。按用药剂最分为4组,每组各5例。各组剂量分别为30、50、72和100×10~6U/天,肌肉注射,连续28天。其中5例治疗前用过强的松龙。耐受性和不良反应:20例病人都未发生严重不良反应,无退出研究者。最大耐受量
The authors studied the tolerability, pharmacokinetics and antiviral effects of high-dose recombinant leukocyte interferon-alpha A (IFN-αA) in 20 DNA polymerase and HBeAg-positive chronic hepatitis B patients. There were 19 males and 1 females, ranging in age from 19 to 47 years old (average 30.4 years). There were 11 cases of chronic persistent hepatitis, 7 cases of chronic active hepatitis and 2 cases of liver cirrhosis. Divided by the agent is divided into 4 groups, each group of 5 cases. Each group dose was 30,50,72 and 100 × 10 ~ 6U / day, intramuscular injection, continuous 28 days. Five of them used prednisolone before treatment. Tolerability and adverse reactions: None of the 20 patients experienced serious adverse reactions without exiting the study. Maximum tolerance