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综合报道近年来作者等对慢性HBV无症状感染的研究结果。处于受“高威胁”的口腔科医务人员和血液透析病人的HBV感染率并不高于一般人群。无症状感染状态的存在,是由于对HBsAg的体液和细胞免疫功能不全。经肝活检的257例,44％诊断为不同类型的慢性肝炎。在肝组织病毒抗原的表型与肝内炎症活动性之间,未发现有明显相关性。感染状态相当稳定。HBeAg/抗-HBe血清转换不是病毒复制与非复制时相的截然转折点。肝内有整合型病毒核酸的个例,可以是血清病毒抗原阴性的基因组携带者。上述结果构成我国“高发地区低反应型”HBV感染的特点。
Comprehensive report in recent years, the author of the study of asymptomatic infection of chronic HBV results. The prevalence of HBV infection in stomatology and hemodialysis patients under “high threat” is not higher than in the general population. The presence of asymptomatic infection is due to humoral and cellular immune dysfunction of HBsAg. Of the 257 patients who underwent liver biopsy, 44% were diagnosed with different types of chronic hepatitis. No significant correlation was found between the phenotype of liver virus antigens and intrahepatic inflammatory activity. The status of infection is quite stable. HBeAg / anti-HBe seroconversion is not a complete turning point in the phase of viral replication and non-replication. An example of an integrative viral nucleic acid in the liver may be a seronegative antigen-negative genomic carrier. The above results constitute our country “high incidence of low-response” characteristics of HBV infection.