发现疟原虫可以对抗疟药产生抗性历时已久。早在1844年Elliotson报告奎宁对疟原虫的疗效降低,1910年Neive等描述了巴西的疟原虫对奎宁有抗性。氯喹从1934年开始被采用,50年代后普遍应用,但1957年在哥伦比亚和柬泰边境已出现恶性疟原虫对氯喹的抗性,1960年经详细的临床和实验研究得到证实。 1960～1961年仅在南美和东南亚证实存 It has been a long time since Plasmodium was found to be resistant to antimalarial drugs. As early as 1844, Elliotson reported that quinine has been shown to reduce the efficacy of quinine against malaria parasites. In 1910 Neive et al. Described the resistance of Plasmodium to quinine in Brazil. Chloroquine has been used since 1934 and has been commonly used since the 1950s. However, chloroquine resistance of P. falciparum has been reported since 1957 in Colombia and the Cambodian borderlands and was confirmed in 1960 by detailed clinical and experimental studies. 1960 ~ 1961 only confirmed in South America and Southeast Asia