作者复习1984～1989年6年间日本皮肤科杂志报道的827例药疹病人,认识到要解释用药物前体(Prodrug)治疗后产生的药疹,了解药物的释放方式是必要的。以药物前体氨苄青霉素碳酯(BAPC)和酞氨苄青霉素(TAPC)为例。它们在试管内本身并无抗菌活性,但在小肠吸收良好,在吸收过程中迅速被水解为氨苄青霉素(ABPC),口服BAPC可达到高浓度的ABPC。故服用药物前体后的药疹可能是由其代谢产物(AB The authors reviewed 827 cases of drug eruption reported by the Japanese Journal of Dermatology during the six years from 1984 to 1989 and recognized that it is necessary to explain the drug release patterns after explaining drug eruptions developed with Prodrug. Take the prodrugs of ampicillin (BAPC) and ampicillin (TAPC) as an example. They have no antimicrobial activity in the test tube themselves, but are well absorbed in the small intestine and rapidly hydrolyzed to ampicillin (ABPC) during the absorption process. High levels of ABPC are achieved with oral BAPC. Therefore, after taking drug precursor drug eruption may be its metabolites (AB