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目的:探讨IgG亚型与新生儿ABO溶血病高胆红素血症的发生及危重程度的关系。方法:对实验室诊断为新生儿ABO溶血病的患儿,用德国欧盟公司的亚型试剂盒测定其血清IgG亚型。结果:153例实验室诊断为新生儿ABO溶血病的患儿中检测出IgG1和IgG3亚型的27例,其中24例发生高胆红素血症,检出IgG3亚型的全部发生高胆红素血症且胆红素增高明显。结论:测定新生儿IgG亚型抗体,可有助于诊断新生儿ABO溶血病高胆红素血症的发生并预测其严重程度。
Objective: To investigate the relationship between IgG subclass and neonatal ABO hemolytic disease hyperbilirubinemia and its severity. Methods: Serum IgG subtypes were determined in children with ABO hemolytic disease diagnosed as neonates by subtype kit of German EU. RESULTS: Totally 27 IgG1 and IgG3 subtypes were detected in 153 laboratory diagnosed neonates with ABO hemolytic disease, of which 24 developed hyperbilirubinemia and all of the IgG3 subtypes were found to be hyperbilirubinely Hyperlipidemia and bilirubin increased significantly. Conclusion: Determination of neonatal IgG subtype antibodies can help diagnose neonatal ABO hemolytic disease hyperbilirubinemia and predict its severity.