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目的:探讨儿茶酚抑素(CST)水平在急性冠状动脉综合征(ACS)患者中的检测价值。方法:将182例ACS患者分为不稳定型心绞痛(UA)组、急性ST段抬高型心肌梗死(STEMI)组、急性非ST段抬高型心肌梗死(NSTEMI)组,分别比较3组与对照组(90例)间血浆CST、去甲肾上腺素(NE)、CST/NE、Gensini评分及心率变异性(HRV)参数的差异。最后,将ACS患者分为心力衰竭(心衰)组和非心衰组,分别比较两组间血浆CST、NE、N末端脑钠肽前体(NT-proBNP)的差异。结果:ACS患者CST、NE水平值均高于对照组(P<0.05),但CST/NE与对照组及各组间比较无统计学差异(P>0.05)。3组间Gensini评分、心率、心律失常发生率,NSTEMI组、STEMI组均高于UA组(P<0.05),HRV参数,NSTEMI组、STEMI组均低于UA组(P<0.05);ACS患者伴心衰时,CST和NT-proBNP浓度均高于不伴心衰的患者(P<0.05),而NE无统计学差异(P>0.05)。结论:CST水平在ACS患者中明显升高,同时与病情轻重明显相关。
Objective: To investigate the diagnostic value of catechin somatostatin (CST) in patients with acute coronary syndrome (ACS). Methods: A total of 182 ACS patients were divided into unstable angina pectoris (UA) group, STEMI group, and acute non-ST segment elevation myocardial infarction (NSTEMI) The difference of plasma CST, norepinephrine (NE), CST / NE, Gensini score and heart rate variability (HRV) between control group (90 cases) Finally, ACS patients were divided into heart failure group and non-heart failure group, and the differences of plasma CST, NE, N-terminal pro-brain natriuretic peptide (NT-proBNP) between the two groups were compared. Results: The levels of CST and NE in ACS patients were significantly higher than those in control group (P <0.05), but there was no significant difference between CST / NE group and control group (P> 0.05). The Gensini score, heart rate, arrhythmia incidence, NSTEMI group and STEMI group were higher than UA group (P <0.05), HRV parameters, NSTEMI group and STEMI group were lower than UA group (P <0.05) With heart failure, CST and NT-proBNP concentrations were higher than those without heart failure (P <0.05), while NE was not statistically different (P> 0.05). Conclusion: The level of CST in patients with ACS was significantly higher than that in patients with mild to severe disease.