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目的探讨肾上腺皮质嗜酸细胞肿瘤的临床和病理学特点。方法回顾性分析7例肾上腺嗜酸细胞肿瘤的临床资料。结果 7例患者中,1例表现为女性男性化,2例表现为皮质醇增多症,4例无特异表现,肿瘤大小1.5 cm×1.5 cm×2 cm～8 cm×8cm×9 cm,包膜完整,与周围没有粘连。切面为灰黄色,光镜下胞质内含丰富的嗜酸颗粒,细胞无明显异型性和核分裂相。3例免疫组化NSE(+)、VIM(+)。7例均诊断为良性肿瘤,手术切除后未见肿瘤复发和转移。结论肾上腺嗜酸细胞肿瘤有其自身的特点,大多是没有功能的,发现时一般肿瘤体积比较大,应该根据肿瘤的病理学特征进行良恶性鉴别,术后需要随访。
Objective To investigate the clinical and pathological features of adrenocortical oncocytoma. Methods The clinical data of 7 patients with adrenal eosinophilic tumors were retrospectively analyzed. Results Of the 7 patients, 1 showed male masculinity, 2 showed cortisol hypersecretion, 4 showed no specific expression. The size of the tumor was 1.5 cm × 1.5 cm × 2 cm ~ 8 cm × 8 cm × 9 cm. Complete, no sticking around. The section is gray-yellow, under the light microscope, the cytoplasm contains abundant acidophilic granules, and the cells have no obvious atypia and mitotic phase. 3 cases of immunohistochemical NSE (+), VIM (+). Seven cases were diagnosed as benign tumor, no tumor recurrence and metastasis after surgical resection. Conclusion Adrenal eosinophilic tumor has its own characteristics, most of them are nonfunctional. When the tumor size is relatively large, it should be differentiated benign and malignant according to the pathological features of the tumor. Postoperative follow-up is needed.