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目的比较VP方案和大剂量丙种球蛋白(HDIVIG)治疗成人特发性血小板减少性紫癜(ITP)的临床疗效。方法2006年1月至2009年1月收治的56例ITP患者,随机分为两组:VP方案组(A组)21例:以长春新碱2mg缓慢静脉滴注,每周1次,连用6周,以后每2周1次,共4次,同时联用强的松口服1mg/(kg.d),有效后强的松逐渐减量至停用;HDIVIG组(B组)35例:给予IVIG0.4g/(kg.d),5d为1个疗程,观察两组的临床疗效。结果A组和B组有效率分别为57.1%和85.7%,两组比较差异有统计学意义(χ2=5.71,P<0.05)。结论VP方案和HDIVIG方案治疗ITP均取得一定疗效,其中HDIVIG方案疗效优于VP方案。
Objective To compare the clinical efficacy of VP regimen and HDIVIG in the treatment of adult idiopathic thrombocytopenic purpura (ITP). Methods Fifty-six patients with ITP admitted between January 2006 and January 2009 were randomly divided into two groups: 21 patients in the VP regimen group (group A): received a slow intravenous infusion of 2 mg vincristine once a week for 6 Week, once every two weeks thereafter, a total of 4 times, at the same time with prednisone oral 1mg / (kg.d), effective after gradual reduction of prednisone to disable; HDIVIG group (B group) 35 patients: given IVIG0.4g / (kg.d), 5d for a course of treatment, the clinical efficacy of the two groups were observed. Results The effective rates of group A and group B were 57.1% and 85.7%, respectively. The difference between the two groups was statistically significant (χ2 = 5.71, P <0.05). Conclusion Both VP and HDIVIG regimens achieved some therapeutic effects in ITP, of which HDIVIG regimen was superior to VP regimen.