从一株海洋来源真菌Penicillium citrinum中分离得到了一个结构新颖的桔霉素衍生物penicitrinol L(1)以及两个已知类似物penidicitrinin B(2)和pennicitrinone A(3)。通过一维和二维核磁以及高分辨质谱等波谱学方法确定了新化合物的结构。此外,化合物1对人白血病HL-60细胞具有中等的抑制活性,化合物3对人黑色素瘤A375细胞具有较弱的抑制活性。 A novel structural derivative of citrinin penicillin L (1) and two known analogues penidicitrinin B (2) and pennicitrinone A (3) were isolated from Penicillium citrinum, a marine fungus. The structures of the new compounds were determined by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. In addition, compound 1 has moderate inhibitory activity on human leukemia HL-60 cells and compound 3 has weaker inhibitory activity on human melanoma A375 cells.