论文部分内容阅读
目的 :探讨bc 1 - 2及p5 3蛋白在Bowen病及Bowen样鳞癌中的表达及其意义。方法 :应用免疫组织化学技术对 1 1例Bowen病及 3例Bowen样鳞癌bc1 - 2和 或p 5 3蛋白的表达进行了检测。结果 :1 1例Bowen病bc1 - 2蛋白阳性者 2例 ( 1 8% ) ,p 5 3蛋白阳性者 3例 ( 2 7% ) ;3例Bowen样鳞癌均见bc1 - 2蛋白表达。Bowen中bc1 - 2蛋白与p 5 3蛋白表达呈显著正相关 (r =0 .76 9,P <0 0 5 )。结论 :Bowen病中bc 1 - 2蛋白的表达与p 5 3基因突变有关 ,并参与了Bowen病的进展及向Bowen样鳞癌演变
Objective: To investigate the expression of bc 1 - 2 and p5 3 protein in Bowen’s disease and Bowen’s squamous cell carcinoma and its significance. Methods: Immunohistochemistry was used to detect the expression of bc1 - 2 and p53 proteins in 11 Bowen ’s disease and 3 Bowen - like squamous cell carcinomas. Results: Two cases (18%) of Bowen ’s disease positive for bc1 - 2 protein and three cases (5%) positive for p5-3 protein were found in Bowen’ s disease. The expression of bc1 - 2 protein was found in all 3 cases of Bowen - like squamous cell carcinoma. Bowen bc1 - 2 protein and p 5 3 protein expression was significantly correlated (r = 0.769, P <0 05). CONCLUSIONS: The expression of bc 1 - 2 in Bowen disease is associated with mutations in the p 5 3 gene and is involved in the progression of Bowen’s disease and evolution to Bowen-like squamous cell carcinomas