To investigate the electrical remodeling and the effects of amiodarone and losartan on electrical remodeling in rapid atrial pacing on rabbit model. Methods 40 normal rabbits were randomly divided into 4 groups: the saline group (control group), amiodarone group, losartan group, ami + los group. All rabbits were raised drugs in a week. The atrial effective refractory period (AERP) was measured. Then, take a rapid atrial pacing (600 bpm) and the AERP was measured after 0.5, 1, 2, 4, 6 and 8 hours pacing and 30 minutes after the termination of rapid pacing. Results ① In control group, after 8 hours rapid pacing, AERP200 and AERP150 were significantly shortened 16.11%±3.1% (P<0.01) and 9.99%±4.2% (P<0.01). And the degree of AERP shortening induced by rapid pacing was greater at basic cycle lengths of 200 ms (BCL200) than that at BCL150. The AERP of amiodarone, losartan group and ami + los group were not shortened during rapid pacing. ② In the control group, after the termination of rapid pacing, the AERP gradually increased. The AERP at all of the BCLS examined recovered to almost the 95.78% and 96.76% of baseline values within the first 10 minutes and recovered to almost the 99.07% and 99.39% of baseline values within the first 30 minutes. Conclusions Short-term atrial rapid pacing can induce the atrial electrical remodeling. Amiodarone and losartan can prevent the electrical remodeling. To investigate the electrical remodeling and the effects of amiodarone and losartan on electrical remodeling in rapid atrial pacing on rabbit model. Methods 40 normal rabbits were randomly divided into 4 groups: the saline group (control group), amiodarone group, losartan group, ami + The atrial effective refractory period (AERP) was measured. Then, take a rapid atrial pacing (600 bpm) and the AERP was measured after 0.5, 1, 2, 4, 6 and Results ① In control group, 16.11% ± 3.1% (P <0.01) and 9.99% ± 4.2% (P <0.01) of AERP200 and AERP150 were significantly shortened after 8 hours pacing and 30 minutes after the termination of rapid pacing. 0.01). And the degree of AERP shortening induced by rapid pacing was greater at basic cycle lengths of 200 ms (BCL200) than that at BCL150. The AERP of amiodarone, losartan group and ami + los group were not shortened during rapid pacing. In the control group, after the termination of rapid pacing, the AERP-bound increased. The AERP at all of the BCLS examined recovered to almost the 95.78% and 96.76% of baseline values ​​within the first 10 minutes and recovered to almost the 99.07% and 99.39% of baseline values ​​within the first 30 minutes. Conclusions Short-term atrial rapid pacing can induce the atrial electrical remodeling. Amiodarone and losartan can prevent the electrical remodeling.