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目的分析正常眼不同视野区域的mfVEP波形特征及实验性暗区对结果的影响,探讨mfVEP用于客观评定视野的可行性。方法以正常青年男性51眼为实验对象,应用四通道mfVEP记录系统进行mfVEP检测,30眼行实验性暗区测试。统计组合反应波振幅、峰时及振幅密度的均数、标准差。组间比较采用单因素方差分析,不同刺激野遮盖前、后mfVEP振幅比较采用配对t检验。结果正常眼mfVEP各位点均能引出较明确的VEP波:其中鼻下、颞下象限组合反应波振幅密度(8.68±3.67、7.84±3.32nV/deg2)较鼻上、颞上象限(5.55±2.22、5.08±1.85nV/deg2)大;反应波从黄斑中心凹向周边逐渐降低(240.36±96.60nV/deg2~1.83±0.73nV/deg2)。遮盖颞下象限及外周3个环刺激野造成形成实验性暗区时,对应区域mfVEP组合反应波多数呈熄灭型(70%及80%);而遮盖鼻下方某两个位点时,对应区域波振幅显著降低(P<0.05)。结论 mfVEP能较准确、客观反映视野不同区域的视功能差异,有望成为法医学客观视野检测手段。
Objective To analyze the characteristics of mfVEP waveform in different visual fields of normal eyes and the influence of experimental dark areas on the results and to explore the feasibility of using mfVEP in objective visual field assessment. Methods Totally 51 eyes of normal young male were used as experimental subjects. Four-channel mfVEP recording system was used for mfVEP test and 30 eyes of experimental dark area test. Statistics combination of the reaction wave amplitude, peak and amplitude density of the mean, standard deviation. One-way analysis of variance was used to compare between groups. The amplitude of mfVEP before and after different stimulation fields were compared by paired t-test. Results All the sites of mfVEP in normal eyes could lead to more definite VEP waves: the amplitudes of combined wave in the subnasal and infratemporal quadrant were (8.68 ± 3.67, 7.84 ± 3.32nV / deg2) higher than those in the superior nasal and superior temporal quadrant (5.55 ± 2.22 , 5.08 ± 1.85nV / deg2). The response wave gradually decreased from the foveal center to the periphery (240.36 ± 96.60nV / deg2 ~ 1.83 ± 0.73nV / deg2). Covering the inferior quadrant of the inferior quadrant and peripheral stimulation of 3 rings resulted in the formation of an experimental dark zone, the majority of the corresponding mfVEP combination reaction waves were extinguished (70% and 80%); while covering some two sites beneath the nose, the corresponding region Wave amplitude was significantly reduced (P <0.05). Conclusion mfVEP can more accurately and objectively reflect the visual function differences in different regions of the visual field, and it is expected to be an objective visual field detection method in forensic science.