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采用新生小鼠颅骨体外培养模型，研究了表皮生长因子调节骨吸收的作用，发现１、１０、１００ｎｇ／ｍｌ的表皮生长因子能增加培养上清液中钙的含量，差异非常显著（Ｐ＜０．００１）．此外发现：表皮生长因子（１ｎｇ／ｍｌ）能刺激培养颅骨释放骨钙素。组织学观察发现：表皮生长因子处理过的颅骨骨吸收活跃。结果提示，表皮生长因子具有强烈刺激骨吸收的作用。
The effects of epidermal growth factor (EGF) on bone resorption were studied using a newborn mouse skull model in vitro. It was found that epidermal growth factor (1, 10, and 100 ng / ml) increased the content of calcium in the supernatant .001). Also found: epidermal growth factor (1ng / ml) can stimulate the development of skull osteocalcin release. Histological observations revealed that epidermal growth factor-treated skull bone was actively absorbed. The results suggest that epidermal growth factor has a strong stimulating effect on bone resorption.