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目的:探索中药复方制剂“健心佳”不同时间窗干预对阿霉素诱导的大鼠心衰的影响,以探求中医药对早期心衰干预的动物实验途径。方法:用阿霉素腹腔注射诱导的大鼠心衰模型,分别从建模后2周和建模后6周予“健心佳”干预,第10周观察死亡率、心肌病理改变、心功能、ET、ANP、ATⅡ。结果:“健心佳”早期干预的大鼠存活率80%,较晚期干预组55%和模型组43%有显著差异(P<0.05);心功能和血浆ANP、ATⅡ等指标的改善有显著差异(P<0.05)。结论“:健心佳”早期干预较晚期干预可提高心衰大鼠的存活率,更有利于对心肌收缩性能和心脏舒张功能的改善以及对神经内分泌过度激活的抑制。
OBJECTIVE: To explore the effect of different time window interventions of traditional Chinese medicine compound preparation “Jinxinjia” on doxorubicin-induced heart failure in rats, in order to explore the animal experimental approaches to early heart failure intervention by Chinese medicine. METHODS: Rat heart failure model induced by intraperitoneal injection of adriamycin was given to 2 weeks after modeling and 6 weeks after modeling. Mortality, myocardial pathological changes and cardiac function were observed at the 10th week. , ET, ANP, ATII. Results: The survival rate of rats treated with “Jianxinjia” was 80%, which was significantly higher than that of the late intervention group (55%) and the model group (43%) (P <0.05). The heart function and plasma ANP, ATII and other indicators improved. There was a significant difference (P<0.05). Conclusions: “Jianxinjia” is more effective than early intervention in improving the survival rate of rats with heart failure, and is more conducive to the improvement of myocardial contractility and diastolic function as well as the inhibition of excessive activation of neuroendocrine.