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钙通道阻滞剂(硝苯啶、维拉帕米、地尔硫(?))已被广泛用于治疗心血管病。皮肤不良反应发生率虽低,但偶尔很严重,如地尔硫(?)引起中毒性上皮坏死溶解;三药均可引起渗出性多形红斑症、多形红斑、剥脱性皮炎。严重反应见于起始治疗2周以内。作者汇集1978～1985年间钙通道阻滞剂的皮肤不良反应379例报告,其中硝苯啶146例(发生率5.8/百万)、维拉帕米153例(16.6/百万)、地尔硫(?)72例(6.5/百万)。379例共493次反应见附表(略)。反应出现时间在给药后平均13日。1例地尔硫(?)引起中毒性上皮坏死溶解,死于呼吸和心力衰竭。
Calcium channel blockers (nifedipine, verapamil, diltiazem (?)) Have been widely used to treat cardiovascular disease. Although the incidence of skin adverse reactions is low, but occasionally very serious, such as diltiazem (?) Caused by toxic epithelial necrosis dissolved; three drugs can cause exudative erythema multiforme, erythema multiforme, exfoliative dermatitis. Serious reaction seen in the initial treatment within 2 weeks. The authors collected 379 cases of skin adverse reactions of calcium channel blockers from 1978 to 1985, including nifedipine 146 (incidence 5.8 / million), verapamil 153 (16.6 / million), diltiazem (?) 72 cases (6.5 / million). 379 cases, a total of 493 times the reaction table (omitted). The reaction appeared on the average of 13 days after administration. One case of diltiazem (?) Caused toxic epithelial necrosis and died of respiratory and heart failure.