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目的观察应用益赛普治疗幼年特发性关节炎患儿,其治疗前后血清肿瘤坏死因子α和骨钙素的变化。方法对2007年6月至2011年2月间诊治的38例幼年特发性关节炎患者,年龄3～13岁(平均5.8岁)在常规抗风湿药物治疗基础上加用益赛普0.4 mg/kg皮下注射,每周2次,连续治疗3个月,治疗前后收集患者血液,分别采用放免法和酶免法测定血清BGP和TNF-α水平。结果 38例患儿治疗12周后ESR和CRP较治疗前均明显下降(P<0.05;P<0.01),TNF-α明显降低(P<0.05),BGP与治疗前对照升高具有统计学意义(P<0.01)。用药期间未发生严重不良反应。结论幼年特发性关节炎活动期有骨质破坏及骨吸收现象;益赛普可通过降低血清TNF-α水平有效缓解幼年特发性关节炎的症状,并改善病情。
Objective To observe the changes of serum tumor necrosis factor-α and osteocalcin in children with idiopathic juvenile idiopathic arthritis before and after treatment with ipsapin. Methods Thirty-eight juvenile patients with idiopathic juvenile arthritis who were diagnosed and treated between June 2007 and February 2011 were aged 3 to 13 years (average 5.8 years old). On the basis of conventional anti-rheumatic drug treatment, the patients were given Yixipu 0.4 mg / kg Subcutaneous injection, twice a week, continuous treatment for 3 months, before and after treatment to collect the patient’s blood, respectively, by radioimmunoassay and enzyme-free serum BGP and TNF-α levels. Results ESR and CRP in 38 children after 12 weeks of treatment were significantly lower than those before treatment (P <0.05; P <0.01), TNF-α significantly decreased (P <0.05) (P <0.01). Serious adverse reactions did not occur during the treatment. Conclusion Idiopathic arthritis has osteoporosis and bone resorption in the active stage. Adipapin can effectively alleviate the symptoms of juvenile idiopathic arthritis by reducing serum TNF-α level and improve the disease.