目的　探讨慢性非细菌性前列腺炎发病机理。方法　测定２２ 例患者血清和前列腺液中的尿酸和肌酐水平与前列腺症状评分进行相关分析。结果　前列腺液中尿酸与肌酐值及前列腺症状评分呈正相关（ Ｐ＜ ００１） 。结论　前列腺体内尿液返流是导致慢性前列腺炎症状的重要因素，前列腺液内增高的尿酸可能是化学性致痛因子。 Objective To explore the pathogenesis of chronic non-bacterial prostatitis. Methods The levels of uric acid and creatinine in serum and prostatic fluid of 22 patients were determined by correlation analysis with prostate symptom score. Results There was a positive correlation between uric acid, creatinine and prostate symptom scores in prostatic fluid (P <001). Conclusions Urinary reflux in the prostate is an important factor leading to the symptoms of chronic prostatitis. Increased uric acid in prostatic fluid may be a chemical pain factor.