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目的探讨趋化因子C-X-C-基元受体7(CXCR7)在子宫颈癌中的表达。方法收集经手术切除并经病理检查确诊的子宫颈癌患者59例为宫颈癌组,宫颈上皮内瘤变(CIN)患者86例为CIN组,并选择同期其他病因手术切除的正常子宫颈组织20例为对照组,分析三组标本的CXCR7阳性表达情况。结果 CXCR7阳性表达率宫颈癌组(88.1%)高于CIN组(45.3%)及对照组(5.0%),差异有统计学意义(P<0.01),CIN组高于对照组(P<0.01)。经Spearman等级相关性分析,CXCR7阳性表达水平与宫颈癌的发生发展呈正相关(r=0.421,P<0.05)。结论 CXCR7在子宫颈癌中呈高表达,且与宫颈癌的发生发展存在一定的相关性。
Objective To investigate the expression of chemokine C-X-C-receptor 7 (CXCR7) in cervical cancer. Methods Fifty-nine patients with cervical cancer who underwent surgical resection and pathological examination were selected as cervical cancer group and 86 patients with cervical intraepithelial neoplasia (CIN) as CIN group. Normal cervical tissue 20 Cases for the control group, analysis of three groups of specimens CXCR7 positive expression. Results The positive expression rate of CXCR7 in cervical cancer group was higher than that in CIN group (45.3% vs 5.0%, P <0.01), and CIN group was higher than that in control group (88.1%) (P <0.01) . The Spearman rank correlation analysis showed that the positive expression of CXCR7 was positively correlated with the occurrence and development of cervical cancer (r = 0.421, P <0.05). Conclusion CXCR7 is highly expressed in cervical cancer and has some correlation with the occurrence and development of cervical cancer.