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中年男性,以持续肉眼血尿伴大量蛋白尿、肾功能减退、血抗肾小球基膜(GBM)抗体阳性起病;肾活检组织学符合新月体肾炎,免疫荧光见IgG沿肾小球毛细血管袢线性沉积,符合抗GBM肾炎,同时亦见肾小球呈结节样改变、肾小管基膜(TBM)增厚、动脉透明变性等,超微结构观察GBM呈均匀一致性增厚,经糖耐量检查确诊糖尿病。该患者最终诊断为抗GBM肾炎合并糖尿病肾病(DN)。
Middle-aged men with persistent gross hematuria with a large number of proteinuria, renal dysfunction, blood anti-glomerular basement membrane (GBM) antibody positive onset; histological renal biopsy in line with crescentic nephritis, immunofluorescence see IgG along the glomerulus Capillary 袢 linear deposition, in line with anti-GBM nephritis, also see glomerular nodular changes, tubular basement membrane (TBM) thickening, transparent arterial degeneration, etc. The ultrastructural observation GBM was uniform thickening, Diabetes mellitus confirmed by glucose tolerance test. The patient eventually diagnosed as having anti-GBM nephritis with diabetic nephropathy (DN).