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味精的主要成分谷氨酸，是一典型的兴奋性氨基酸，其神经毒性作用已受到广泛关注。本实验采用健康昆明种小白鼠，从妊娠后的第４天开始腹膜腔注射谷氨酸钠（剂量分别为６０ｍｇ／ｋｇ，３０ｍｇ／ｋｇ，１０ｍｇ／ｋｇ，隔日一次）。于妊娠后的第１８天检查胎鼠，取脑Ｃａｒｎｏｒｙｓ液固定，常规石蜡切片，ＨＥ、Ｆｅｕｌｇｅｎ和Ｎｉｓｓｌ染色。进行形态观察，图像分析仪随机测定大脑皮质１００个神经元的Ｆｅｕｌｇｅｎ与Ｎｉｓｓｌ染色的灰度值，作定量分析。结果显示，各实验组与对照组均未见形态异常，实验组各项参数与对照组比较，差异有显著性，Ｐ＞０．０５。
The main component of monosodium glutamate, glutamate, is a typical excitatory amino acids, its neurotoxic effects have received widespread attention. In this experiment, healthy Kunming mice were used. Glutamic acid (60mg / kg, 30mg / kg, 10mg / kg, once every other day) was injected intraperitoneally from the 4th day after pregnancy. The fetuses were examined on the 18th day after gestation. Brain Carnorys fluid was fixed, paraffin sections were stained, HE, Feulgen and Nissl staining. Morphological observation was performed. The image analyzer randomly measured the gray values of Feulgen and Nissl staining of 100 neurons in the cerebral cortex for quantitative analysis. The results showed that the experimental group and the control group were not seen morphological abnormalities, the experimental group parameters and control group, the difference was significant, P> 0.05.