【摘 要】
：
目的评估伐尼克兰联合心理干预措施对轻中度慢性阻塞性肺疾病（COPD）吸烟患者烟草依赖的疗效和安全性。方法选取轻中度COPD烟草依赖的患者108例,随机分为干戒组、伐尼克兰组、伐
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目的评估伐尼克兰联合心理干预措施对轻中度慢性阻塞性肺疾病（COPD）吸烟患者烟草依赖的疗效和安全性。方法选取轻中度COPD烟草依赖的患者108例,随机分为干戒组、伐尼克兰组、伐尼克兰＋心理干预（干预组）三组,对伐尼克兰组及干预组给予口服12周伐尼克兰,干预组并给予戒烟咨询及心理干预,随访至24周,观察戒烟者的戒烟率、肺功能变化、不良反应、戒断症状及复吸率。结果干预组12周和24周持续戒烟率分别为77.8%和75%,伐尼克兰组分别为55.6%和41.7%,干戒组分别为25%和8.3%,三组之间差异有统计学意
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