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目的:观察丙氨酰谷氨酰胺双肽对胃癌化疗患者免疫功能的影响。方法:进展期胃癌化疗患者60例,随机分为对照组和试验组,对照组采用肠外营养(TPN)支持,试验组在TPN基础上加用丙氨酰谷氨酰胺双肽注射液。化疗后第1天开始对两组患者行营养支持,时间1周。于化疗前及化疗后第1天、第8天分别抽取外周血测定IgG、IgA、IgM和T淋巴细胞亚群CD_3~+、CD_4~+、CD_8~+,及(CD_4~+)/(CD_8~+)比值。结果:化疗后第1天,两组患者的各项免疫指标均有所下降;化疗后第8天,试验组的各项免疫指标均有所恢复,其中CD_3~+、CD_4~+和(CD_4~+)/(CD_8~+)比值与对照组有统计学差异(P<0.05)。两组患者在观察期间均无严重并发症。结论:含丙氨酰谷氨酰胺双肽的营养能有效改善和增强胃癌患者化疗后机体的免疫功能。
Objective: To observe the effect of alanyl-glutamine dipeptide on immune function in patients with gastric cancer undergoing chemotherapy. Methods: Sixty patients with advanced gastric cancer were randomly divided into control group and experimental group. The control group was given parenteral nutrition (TPN). In the experimental group, alanyl glutamide double peptide injection was added on the basis of TPN. On the first day after chemotherapy, nutrition support was given to both groups for one week. Serum IgG, IgA, IgM and T lymphocyte subsets CD_3 ~ +, CD_4 ~ +, CD_8 ~ + and CD_4 ~ + / CD_8 were determined before chemotherapy and on day 1 and day 8 after chemotherapy ~ +) Ratio. Results: On the first day after chemotherapy, the immunological indexes decreased in both groups. On the 8th day after chemotherapy, all the immune indexes in the experimental group recovered, including CD_3 ~ +, CD_4 ~ + and CD_4 ~ +) / (CD_8 ~ +) ratio and the control group were statistically significant (P <0.05). Two groups of patients in the observation period without serious complications. Conclusion: The nutrition of alanyl glutamine dipeptide can effectively improve and enhance the immune function of gastric cancer patients after chemotherapy.