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目的：探讨某些心血管疾病时血浆内皮素（ＥＴ）的变化及其临床意义。方法：采用放射免疫法对３４例正常人与３４例急性心肌梗塞（ＡＭＩ）、４３例不稳定型心绞痛（ＵＡＰ）、２５例高血压病（ＨＴ）及２１例充血性心力衰竭（ＣＨＦ）患者分别进行了外周血浆ＥＴ水平的测定。结果：ＡＭＩ、ＨＴ及ＣＨＦ组血浆ＥＴ水平明显高于正常对照组（Ｐ＜００１），ＵＡＰ组血浆ＥＴ水平与正常对照组相比无显著性差异（Ｐ＞００５），ＡＭＩ组及ＣＨＦ组不同心功能分级及ＨＴ组不同分期之间，随病情加重，血浆ＥＴ水平有升高的趋势（Ｐ＜００１）。结论：血浆ＥＴ浓度与ＡＭＩ、ＵＡＰ、ＨＴ及ＣＨＦ的病理生理过程存在较为密切的关系。
Objective: To investigate the changes of plasma endothelin (ET) and its clinical significance in some cardiovascular diseases. Methods: Radioimmunoassay (RIA) was used to detect 34 patients with AMI, 43 patients with unstable angina pectoris (UAP), 25 hypertensives (HT) and 21 patients with congestive heart failure (CHF) Peripheral blood plasma ET levels were measured. Results: The levels of plasma ET in AMI, HT and CHF groups were significantly higher than those in normal control group (P <001). There was no significant difference in ET level between UAP group and normal control group (P> 005) In CHF group, there was a trend of increasing ET level (P <001) with different cardiac function grade and different stages of HT group. Conclusion: There is a close relationship between plasma ET concentration and the pathophysiological process of AMI, UAP, HT and CHF.