[Objective] To discuss the protective effects of Coriolus versciclor polysaccharides on liver injury of mice induced by CCl4.[Methods]40 male Kunming mice at four moths old were randomly divided into four groups,which were control group,model group,C. versciclor polysaccharides protection group and feeds + C. versciclor polysaccharides group. Mice were fed for 8 d. On 2 h after final administration,intraperitoneal injection of blend oil solution was carried out was carried out in control group. And in other groups,intraperitoneal injection of0. 15% CCl4 blend oil solution( 10 mL / kg) was conducted. After 18 h,eyeballs were collected and serum was isolated. Livers were taken out and the hepatosomatic index was calculated. Liver homogenate was prepared and the ALT and AST were detected,as well as the SOD and NOS activities,and MDA,GSH and NO contents.[Results] Compared with model group,C. versciclor polysaccharides in different administration ways reduced the hepatosomatic index( P < 0. 05) and MDA content( P < 0. 001),lowered the AST activity in serum( P < 0. 05),the NOS activity and the NO content( P < 0. 01),and enhanced the SOD activity and GSH content( P < 0. 01).[Conclusions] C. versciclor polysaccharides in different administration ways protected the liver injury of mice induced by CCl4. [Objective] To discuss the protective effects of Coriolus versciclor polysaccharides on liver injury of mice induced by CCl4. [Methods] 40 male Kunming mice at four moths old were randomly divided into four groups, which were control group, model group, C. versciclor polysaccharides protection group and feeds + C. versciclor polysaccharides group. Mice were fed for 8 d. On 2 h after final administration, intraperitoneal injection of blend oil solution was carried out was carried out in control group. And in other groups, intraperitoneal injection of0 After 18 h, eyeballs were collected and serum was isolated. Livers were taken out and the hepatosomatic index was calculated. Liver homogenate was prepared and the ALT and AST were detected , as well as the SOD and NOS activities, and MDA, GSH and NO contents. [Results] Compared with model group, C. versciclor polysaccharides in different administration ways reduced the hepatosomatic index (P <0. (P <0. 01), and enhanced the SOD activity and GSH content (P <0.05) and MDA content (P <0.01). [Conclusions] C. versciclor polysaccharides in different administration ways protected the liver injury of mice induced by CCl4.