现代化疗领域中已设计出许多杀菌和溶菌作用很强的抗生素,但至今一些新的和较好的抗生素对非生长细菌无能为力。已知各种抗生素和非生长细菌接触后,这些细菌依然存活,这种性质被称为表型耐药性(Phe-notypic tolerance)。事实上,这种性质是挑选营养缺陷型突变株的青霉素富集技术的基础。表型耐药性可认为是抗生素杀菌作用的普遍性障碍。 Many antibacterial and bacteriolytic antibiotics have been devised in the field of modern chemotherapy, but to date some new and better antibiotics have been rendered useless by non-growing bacteria. It is known that these bacteria still survive after contact with various antibiotics and non-growth bacteria, a property known as Phe-notypic tolerance. In fact, this property is the basis for selection of penicillin-enriched technology for auxotrophic mutants. Phenotypic resistance can be considered as a universal barrier to the antibacterial effect of antibiotics.