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为了深入了解氯喹药代动力学有关情况 ,用高效液相色谱检测 4名志愿者口服氯喹总量分别为 6 0 0mg、6 0 0mg、90 0mg和 12 0 0mg后 ,血药浓度 16 8h后尚有 141μg/L、134μg/L、2 0 8μg/L和 2 98μg/L ,均明显高于有效杀灭疟原虫 2 0 μg/L浓度。用单剂 6 0 0mg和首日 6 0 0mg ,次日 30 0mg氯喹治疗间日疟现症病人各 1例 ,追踪观察 2 8h均无症状复发和原虫再现 ,获得痊愈。结果表明口服氯喹在人体内清除非常缓慢 ,维持有效杀灭疟原虫时间长 ,是治疗间日疟、三日疟和卵型疟的首选药。
In order to further understand the chloroquine pharmacokinetics, four volunteers using high performance liquid chromatography oral total chloroquine were 600 mg, 600 mg, 90 0 mg and 120 mg, the plasma concentration of 16 8 h after With 141μg / L, 134μg / L, 208μg / L and 2 98μg / L, were significantly higher than the effective kill malaria parasites 20μg / L concentration. A single dose of 600 mg and the first day 600 mg, the next day 30 0mg chloroquine treatment of patients with one case of Plasmodium falciparum were observed follow-up 28 h were symptom-free recurrence and protozoan reproduction, get cured. The results showed that orally administered chloroquine was very slowly cleared in the human body and was effective in killing Plasmodium for a long period of time. It is the drug of choice for the treatment of Plasmodium vivax, Plasmodium malaria and Egg malaria.