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本实验采用ＳＤ大鼠复制急性腹膜炎的动物模型，观察注菌后４８小时外周血及门静脉血内毒素水平及血谷丙转氨酶（ＧＰＴ），肿瘤坏死因子（ＴＮＦ）的变化；同时检查外周血及肝匀浆中黄嘌呤氧化酶（ＸＯＤ）、谷胱甘肽（ＧＳＨ）、丙二醛（ＭＤＡ）等。结果表明：腹膜炎大鼠外周血、门脉血内毒素水平、血ＧＰＴ、ＴＮＦ及血和肝匀浆中ＸＯＤ、ＭＤＡ水平均显著升高，而血和肝匀浆中ＧＳＨ含量则明显降低，与对照组比有显著差异（Ｐ＜０．０１）。从而提示：腹膜炎时，内毒素血症的形成，细胞因子的释放及脂质过氧化与肝损害之间有一定联系。
In this study, SD rat model of acute peritonitis was used to observe the changes of blood endotoxin and GPT and TNF in peripheral blood and portal vein 48 hours after injection. The peripheral blood and Liver homogenate xanthine oxidase (XOD), glutathione (GSH), malondialdehyde (MDA) and so on. The results showed that peripheral blood, portal blood endotoxin levels, blood GPT, TNF, and XOD, MDA levels in blood and liver homogenates were significantly increased in peritonitis rats, but GSH levels in blood and liver homogenates were significantly decreased There was significant difference between the control group and the control group (P <0.01). Thus prompted: peritonitis, the formation of endotoxemia, the release of cytokines and lipid peroxidation and liver damage have a certain relationship.