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对11条感染性休克的清醒狗的观察显示早期氧耗量((?)O_2)增加较远 Dubois 法估计值为高;晚期(?)O_2明显下降,表明细胞氧化代谢严重受抑。感染早期心指数(CI)主要随(?)O_2而变化,提示心功能良好。在心排出量增加时,动静脉血氧含量差缩小,提示这种现象不是适应性反应。后期 CI 与(?)O_2呈正相关,提示全身代谢抑制与心功能明显减退互为因果。随着休克的发展,氧摄取率下降,表明组织细胞摄氧功能严重受损。作者认为感染性休克时保护和改善细胞功能非常重要。
The observation of awake dogs with septic shock in 11 seasons showed that the early oxygen consumption (? O 2) increased more than the long-term Dubois method, and the late (?) O 2 decreased significantly, indicating that the cellular oxidative metabolism was severely inhibited. Early heart index (CI) changes mainly with (?) O_2, suggesting that cardiac function is good. In the cardiac output increases, arteriovenous oxygen difference narrowed, suggesting that this phenomenon is not an adaptive response. The posterior CI was positively correlated with (?) O 2, suggesting that the systemic metabolic inhibition and cardiac function decreased significantly each other as a causal factor. With the development of shock, oxygen uptake rate decreased, indicating that tissue cells have a serious oxygen uptake damage. The authors believe it is important to protect and improve cell function during septic shock.