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少数接受肝素的患者可发生血小板减少及动脉血栓形成,此时需改换其它抗凝治疗。确诊肝素相关性血小板减少较困难,但又十分重要。已知该类患者血清中存在一种肝素依赖性血小板聚集因子,作者对检测该因子试验的敏感性和特异性及其诊断价值进行了研究。观察组14例考虑肝素相关性血小板减少,诊断标准是:(1)治疗前无血小板减少;(2)肝素治疗中发生血小板减少(<150,000/mm~3);(3)排除其它原因引起的血小板减少。对照组为:非肝素引起的消耗性血小板减少病人16例、接受肝素而无血小板减少病人14例及健康人13名。作者将健康人血小板、待测
A small number of patients receiving heparin can occur thrombocytopenia and arterial thrombosis, this time need to change other anticoagulant therapy. Diagnosis of heparin-related thrombocytopenia more difficult, but very important. It is known that there is a heparin-dependent platelet aggregation factor in the sera of these patients. The authors investigated the sensitivity and specificity of this factor assay and its diagnostic value. The observation group of 14 patients considered heparin-related thrombocytopenia, the diagnostic criteria are: (1) no thrombocytopenia before treatment; (2) thrombocytopenia in heparin therapy (<150,000 / mm 3); (3) Thrombocytopenia. The control group consisted of 16 patients with non-heparin-induced wasting thrombocytopenia, 14 patients receiving heparin without thrombocytopenia, and 13 healthy individuals. The author will be healthy human platelets, measured