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目的比较多发性硬化症(MS)患者不同空间频率下的图形视觉诱发电位(P-VEP)与正常者是否有差别。方法将2011年9月-2012年4月就诊并确诊为MS患者18例(36只眼)及正常志愿者20例(40只眼)分别进行高(15′)、低(60′)空间频率下P-VEP检查,比较在2种不同空间频率下两组之间的差异。结果 MS患者P-VEP在高空间频率下P100波潜伏时为(120.50±13.04)ms,比正常者(109.21±5.38)ms延迟(P<0.05),在低空间频率下P100波潜伏时为(109.57±12.87)ms,比正常者(103.31±5.45)ms延迟(P<0.05)。MS患者在高空间频率下P100波振幅为(9.17±5.69)μV,比正常者(15.69±8.45)μV降低(P<0.05),在低空间频率下P100波振幅为(11.93±16.75)μV,与正常者振幅(13.47±9.24)μV相比差异无统计学意义(P>0.05)。将MS患者组按照矫正视力的不同分为视力≥1.0组和<1.0组,其中矫正视力≥1.0组在高空间频率下潜伏时为(113.43±8.28)ms,振幅为(12.94±5.46)μV;低空间频率下潜伏时为(111.13±11.50)ms,振幅为(11.57±5.60)μV。矫正视力<1.0组在高空间频率下潜伏时为(126.69±13.49)ms,振幅为(5.87±3.43)μV;低空间频率下潜伏时为(108.26±14.11)ms,振幅为(12.24±5.82)μV。矫正视力不同的两组在低空间频率下潜伏时和振幅之间差异无统计学意义(P>0.05)。结论与正常者相比,MS患者的P-VEP表现为潜伏时的延迟及振幅的降低,其中高空间频率下的视觉诱发电位更为敏感。在临床应用中,高空间频率下的视觉诱发电位可能能作为评价MS患者视功能的重要依据。
Objective To compare the differences of P-VEP at different spatial frequencies between patients with multiple sclerosis (MS) and normal subjects. Methods Twenty-eight patients (36 eyes) diagnosed as MS and 20 patients (40 eyes) with normal volunteers from September 2011 to April 2012 were selected for high (15 ’), low (60’) spatial frequency Under P-VEP examination, the differences between the two groups were compared at 2 different spatial frequencies. Results The P-wave latency of P-VEP was (120.50 ± 13.04) ms at high spatial frequency in MS patients, which was longer than 109.21 ± 5.38 ms in normal subjects (P <0.05) 109.57 ± 12.87) ms, which was delayed by 103.31 ± 5.45 ms (P <0.05). The amplitude of P100 wave in MS patients was (9.17 ± 5.69) μV, higher than that of normal subjects (15.69 ± 8.45 μV) (P <0.05), and amplitude of P100 wave was (11.93 ± 16.75) μV in low spatial frequencies. There was no significant difference (P> 0.05) between the amplitude and normal amplitude (13.47 ± 9.24 μV). According to the corrected visual acuity, MS patients were divided into visual acuity ≥1.0 group and <1.0 group, in which corrected visual acuity≥1.0 group was (113.43 ± 8.28) ms and amplitude was (12.94 ± 5.46) μV at high spatial frequency; Latency at low spatial frequency was (111.13 ± 11.50) ms and amplitude was (11.57 ± 5.60) μV. The corrected visual acuity <1.0 group was (126.69 ± 13.49) ms with amplitude of (5.87 ± 3.43) μV at high spatial frequency and (108.26 ± 14.11) ms with amplitude of (12.24 ± 5.82) ms at low spatial frequency μV. There was no significant difference in latency and amplitude between two groups with different corrected visual acuity at low spatial frequency (P> 0.05). Conclusion Compared with normal subjects, P-VEP in MS patients showed latency delay and amplitude decrease, and the visual evoked potentials were more sensitive in high spatial frequency. In clinical applications, visual evoked potentials at high spatial frequencies may serve as an important basis for evaluating visual function in patients with MS.