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抗痉剂如苯妥英钠与乙琥胺等可引起系统性红斑狼疮(SLE),作者报导1例卡马西平引起的SLE,停药后随即好转。患者女性,30岁,开始呈复杂性癫痫部分发作,检查发现右颞叶占位病灶,经手术部分切除,术后癫痫发作仍持续存在,治疗用卡马西平1g/日和苯巴比妥120mg/日。一年后发生关节疼痛、僵硬,累及手、脚、腕、肘、膝及臀部,手脚表面出现红斑状皮疹,双目瘙痒。住院期间有胸膜炎性胸痛,检查除在手脚表面见血管炎性皮疹外,其它无特殊,无关节肿胀。眼科检查正常,血红蛋白124g/L,白细胞计数2.4×10~9/L(中性76%,淋巴20%,单核4%),血小板计数200×10~9/L,血沉第一小时44mm,尿、电解质和肝功能正常,抗
Anticonvulsants such as phenytoin sodium and ethylsuccinate can cause systemic lupus erythematosus (SLE), the authors report a case of carbamazepine-induced SLE, immediately after stopping the improvement. Female patients, 30 years old, began a complex epilepsy seizures, check the right temporal lobe occupying lesions, partial resection after surgery, postoperative seizures persist, treatment with carbamazepine 1g / day and phenobarbital 120mg /day. A year after the joint pain, stiffness, involving the hands, feet, wrists, elbows, knees and buttocks, hand and foot surface erythema rash, binocular itching. During hospitalization, pleuritic chest pain, check the surface of the hands and feet in addition to see vascular inflammatory rash, the other no special, no joint swelling. The ophthalmological examination was normal with a hemoglobin of 124 g / L, a white blood cell count of 2.4 × 10 9 / L (neutral 76%, lymphoid 20%, mononuclear 4%), a platelet count of 200 × 10 9 / L, Urine, electrolytes and liver function normal, anti