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目的:观察评价腹腔恒温循环热灌注化疗治疗盆腹腔恶性肿瘤的疗效及安全性。方法:对2013年7月至2014年1月在我科住院的12例进展期盆腹腔恶性肿瘤患者进行手术联合腹腔恒温循环热灌注化疗,观察其疗效及毒副反应,评估其安全性。结果:治疗后3例合并恶性腹水的患者中2例腹水全部消失,1例腹水部分缓解,有效率为100%;治疗后患者KPS评分上升,肿瘤标志物下降,生活质量得到明显提高;除Ⅰ~Ⅱ级消化系统毒性反应外,未发生其他毒副反应。结论:腹腔恒温循环热灌注化疗技术安全、有效,疗效显著,值得临床推广应用。
Objective: To evaluate the efficacy and safety of intraperitoneal hyperthermic thermo-perfusion chemotherapy in the treatment of pelvic malignant tumors. Methods: From July 2013 to January 2014, 12 patients with advanced pelvic malignant tumor who were hospitalized in our department were treated with intraperitoneal thermo-perfusion chemotherapy by thermo-perfusion. The curative effect and toxicity were observed and the safety was evaluated. Results: After treatment, 2 cases of ascites disappeared in 3 cases with malignant ascites and 1 case of ascites was partly relieved with an effective rate of 100%. After treatment, KPS score increased, tumor markers decreased and quality of life improved significantly. ~ Ⅱ grade digestive toxicity, no other side effects. Conclusion: The technique of intraperitoneal hyperthermic thermal perfusion chemotherapy is safe, effective and effective, which is worthy of clinical application.