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心脏遭受短暂缺血或高温处理后均产生早期和延迟保护效应.缺血预适应的心脏保护作用与内源性活性物质有关.辣椒素敏感的感觉神经的主要递质降钙素基因相关肽(CGRP)介导缺血预适应的早期和延迟保护作用.CGRP介导的预适应能保护内皮细胞.热应激的早期和延迟保护也与内源性CGRP释放有关.某些药物如硝酸甘油诱导的预适应可能与其促CGRP释放有关.这些结果表明CGRP可能是一种内源性心肌保护物质,并在预适应的保护效应中起重要作用.
Cardioprotective effects of transient ischemic or hyperthermic treatment of the heart are both delayed and delayed.The cardioprotective effects of ischemic preconditioning are related to endogenous active substances.The main transmitter of capsaicin-sensitive sensory neurons is calcitonin gene-related peptide ( CGRP) mediates the early and delayed protection of ischemic preconditioning.CGRP-mediated preconditioning protects endothelial cells.Early and delayed protection of heat stress is also associated with the release of endogenous CGRP.Some drugs such as nitroglycerin induce Of preconditioning may be related to its release of CGRP.These results suggest that CGRP may be an endogenous myocardial protective substance and play an important role in the protective effect of preconditioning.