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线粒体复合体Ⅰ位于线粒体内膜上,又称NADH-CoQ氧化还原酶,由45个亚单位组成[1]。单粒子电子显微镜显示无论是原核细胞还是真核细胞的复合体Ⅰ均有1个L型整体结构[2]。复合体Ⅰ的疏水性跨膜臂镶嵌在线粒体内膜中,而亲水性头部伸入线粒体基质中。膜表面臂包含有1个以核黄素单核苷酸(FMN)为辅基的黄素蛋白、8个以Fe-S簇为辅基的
Mitochondrial complex I is located in the mitochondrial inner membrane, also known as NADH-CoQ oxidoreductase, composed of 45 subunits [1]. Single-particle electron microscopy showed that either the prokaryotic or the eukaryotic complex I have a L-type structure [2]. The hydrophobic transmembrane arm of complex I is embedded in the mitochondrial inner membrane, while the hydrophilic head extends into the mitochondrial matrix. The membrane surface arm contains a riboflavin single nucleotide (FMN) as a prosthetic group flavoprotein, eight with Fe-S cluster as a secondary