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目的··:探讨阿片依赖者在戒断反应期易发生猝死的机理。方法··:采用免疫组化、细胞培养、核素掺入、ELISA等方法 ,研究比较26例用药模式相近的阿片依赖者在戒断反应期与脱毒治疗后的细胞免疫功能 ,并与健康对照组进行统计分析。结果··:慢性阿片依赖者在戒断反应期CD4+数目减少 ,CD4 +/CD8 +比例降低 ,PBMC合成DNA的能力下降 ,产生IL -2的水平降低 ,血清中免疫抑制性因子sIL -2R水平显著升高 ;上述免疫参数与健康对照组比较差异显著。经脱毒治疗 ,在躯体戒断症状消失后 ,免疫功能提高 ,各项免疫参数前后配对比较差异明显 ,但仍低于正常水平。结论·· :阿片依赖损害人体免疫功能 ,特别是在戒断反应期损害程度严重 ,继而引起机体对外界环境刺激的应激反应降低 ,易致猝死
Objectives: To investigate the mechanism of sudden death in opiate dependent patients during withdrawal reaction. Methods · · ·: immunohistochemistry, cell culture, radionuclide incorporation, ELISA and other methods to study the comparison of 26 modes of opioid dependence in withdrawal mode reaction and detoxification treatment of cellular immune function, and health and Control group for statistical analysis. Results · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · Significantly increased; the above immune parameters and the healthy control group difference was significant. After detoxification treatment, the immune function was improved after the withdrawal of somatosensory symptoms disappeared, and the pairing of immune parameters was significantly different, but still below the normal level. Conclusions ··: Opioid dependence on human immune function damage, especially in the withdrawal period of severe damage, and then cause the body to the external environment to reduce the stress response to stress and cause sudden death