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AIM:To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer.METHODS:From 2003 to 2009,7 patients with paraaortic lymph node recurrence(1-3 lesions)from colorectal cancer were treated with stereotactic body radiotherapy.Total gross tumor volumes ranged from 4 to 40 mL.The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions.RESULTS:One and 3 year overall survival rates were 100%and 71.4%,respectively,and median survival was 37 mo.GradeⅣintestinal obstruction was reported in 1 of 7 patients.This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy=3.6 mL.However,6 patients received an intestinal maximum point dose of<51 Gy and V45Gy of<1 mL,and did not develop any severe complications.CONCLUSION:This pilot study suggests selected paraaortic lymph node recurrence(1-3 closed lesions) that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy.
AIM: To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer. METHODS: From 2003 to 2009, 7 patients with paraaortic lymph node recurrence (1-3 lesions) from colorectal cancer were treated with stereotactic body radiotherapy.Total gross tumor volumes ranged from 4 to 40 mL.The doses were escalated from 36 Gy / patient to 51 Gy / patient and were delivered in 3 fractions.RESULTS: One and 3 year overall survival rates were 100% and 71.4% respectively, and median survival was 37 mo.Grade IVintestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy = 3.6 mL.However, 6 patients received an intestinal maximum point dose of <51 Gy and V45 Gy of <1 mL, and did not develop any severe complications. CONCLUSION: This pilot study suggests selected paraaortic lymph node recurrence (1-3 closed lesions) that failed to respond to chemot herapy can be potentially salvaged by stereotactic body radiotherapy.