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长期以来,核磁共振光谱主要作为有机分子结构测定的工具.近十余年来随着仪器性能的不断提高及方法的完善,用核磁共振进行药物定量分析在国外已取得广泛的进展,例如片剂、注射剂、胶束等含量,均取得较满意的结果,使核磁共振成为药物分析的又一有力工具.国内至今尚未见这方面报导.蒿甲醚是由菊科植物黄花蒿(Artemisia annua L.)中分出的青蒿素还原并甲基化的β体产物,结构如下:
For a long time, NMR spectroscopy has mainly been used as a tool for measuring the molecular structure of organic molecules.With the continuous improvement of instrument performance and the improvement of methods over the past ten years, the quantitative analysis of drugs by nuclear magnetic resonance has made extensive progress abroad, for example, tablets , Injections, micelles and other content, have achieved more satisfactory results, the NMR as a powerful tool for drug analysis so far has not been reported in this regard .Artemether is composed of the Compositae Artemisia annua (Artemisia annua L.) ) Of artemisinin reduction and methylation of β-body products, the structure is as follows: