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HLA A2wasoneofthefirstHLA Aallelestobedis coveredbyserologicmethodandthemostcommonphenotypefoundinhumanbeingwithafrequencyof 17%~ 4 4 %invariousethnicgroups Todate ,itisthemostheterogenousHLA A2specificitywithovertwenty fivesubtypesde scribed ,thesesubtyp