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采用免疫组化技术，分析了４０例乳腺癌石蜡标本主要组织相容性抗原ＨＬＡ－ＤＲ与各项临床病理参数和生存预后的关系。根据ＨＬＡ－ＤＲ阳性细胞的多少，４０例病人分成两组：高阳性组（ＧＨ，＞３０％）和低阳性组（ＧＬ，≤３０％）。结果显示：①ＨＬＡ－ＤＲ表达与原发灶大小、淋巴结转移数、ＴＮＭ分期、组织学分级无关，但与癌周淋巴细胞浸润显著相关（Ｐ＜０．０５）；②高阳性组各时点生存率及总体生存率均显著高于低阳性组（Ｐ＜０．０５）。资料提示，ＨＬＡ－ＤＲ表达对判断乳腺癌预后生存有较高的价值
Immunohistochemical technique was used to analyze the relationship between major histocompatibility antigen (HLA-DR) and clinical pathological parameters and survival prognosis in 40 paraffin-embedded breast cancer specimens. Based on the number of HLA-DR positive cells, 40 patients were divided into two groups: high positive (GH, >30%) and low positive (GL, ≤30%). The results showed that: 1The expression of HLA-DR was not related to the size of primary tumor, the number of lymph node metastasis, TNM stage, histological grade, but was significantly related to lymphocytic infiltration (P<0.05); 2 High-positive group survived at each time point The rate and overall survival rate were significantly higher than those in the low-positive group (P<0.05). Data suggest that HLA-DR expression has a higher value in determining the prognosis and survival of breast cancer