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目的探讨老年病人难辨梭状芽胞杆菌性结肠炎的病因、诊断及防治措施。②方法对８例老年病人难辨梭状芽胞杆菌性结肠炎进行回顾性分析，采用Ｇｅｏｒｇｅ方法对难辨梭状芽胞杆菌分离、鉴定，仿Ｃｈａｎｇ法行细胞毒素测定。③结果本组病人所用抗生素的种类繁多，以头孢菌素类和氨苄西林最多，在使用抗生素后３～１４ｄ内发生腹泻，重者伴腹膜炎。４例行纤维结肠镜检查均见有小片至大斑片假膜附着，严重者融合成片。治疗措施为停用原抗生素，应用万古霉素和（或）甲硝唑及加强支持疗法。８例中治愈７例，死亡１例。④结论老年人特别是术后使用广谱抗生素者易诱发难辨梭状芽胞杆菌性结肠炎。
Objective To investigate the etiology, diagnosis, prevention and treatment of Clostridium difficile colitis in elderly patients. ② Methods Retrospective analysis was performed on eight cases of Clostridium difficile colitis in elderly patients. The George method was used to isolate, identify, and imitate the cytotoxic assay of Clostridium difficile. The results of this group of patients with a wide range of antibiotics used to cephalosporins and ampicillin up to 3 to 14 days after the use of antibiotics in the diarrhea, severe cases with peritonitis. 4 routine colonoscopy showed a small piece of film attached to the large patch pseudomembrane, severe fusion into pieces. Treatment measures to disable the original antibiotics, vancomycin and / or metronidazole and strengthen supportive therapy. In 8 cases, 7 cases were cured and 1 died. ④ Conclusion Elderly patients, especially after broad-spectrum antibiotics are easy to induce Clostridium difficile colitis.