论文部分内容阅读
目的探讨内分泌治疗合并早期放射治疗对高危前列腺癌患者根治术后的局部控制及近期生存率的影响。方法收集首都医科大学附属北京朝阳医院14例高危组前列腺癌根治术后行三维适形放射治疗(three dimension-conformal radiotherapy,3D-CRT)或调强放射治疗(intensive modulation radiotherapy,IMRT)联合内分泌治疗的患者,收集患者基本信息、手术信息,并随访放射治疗期间的相关合并症、术后及放射治疗后前列腺特异性抗原(prostate specific antigen,PSA)变化与生存状态,并进行统计学分析。结果 14例患者治疗后随访时间2~52个月,平均随访时间20个月。在放射治疗疗期间,5例患者出现轻度尿频、尿急,2例出现轻度腹泻、腹胀,1例患者出现白细胞一过性降低,血红蛋白、血小板无异常,无其他合并症发生;1例患者放射治疗疗后24个月,PSA由最低0.056 ng/m L升高至6 ng/m L,但无明显局部复发和远处转移迹象,恢复比卡鲁胺及亮丙瑞林治疗5个月后,PSA降至1.539 ng/m L。其他13例患者无生化指标反弹及临床局部复发。结论高危前列腺癌根治术后,早期辅助放射治疗联合内分泌治疗可以改善患者局部控制及近期生存率。
Objective To investigate the effect of endocrine therapy combined with early radiotherapy on local control and short-term survival after radical surgery in patients with high-risk prostate cancer. Methods Thirteen patients with high-risk prostate cancer who underwent radical prostatectomy in Beijing Chaoyang Hospital affiliated to Capital Medical University underwent three-dimensional conformal radiotherapy (3D-CRT) or intensive modulation radiotherapy (IMRT) combined with endocrine therapy The patients’ basic information and operation information were collected. The related complications during radiotherapy, the postoperative and post-radiotherapy prostate specific antigen (PSA) status and survival status were collected and analyzed statistically. Results 14 patients were followed up for 2 to 52 months after treatment, with an average follow-up time of 20 months. During radiotherapy, mild urinary frequency, urinary urgency, mild diarrhea and bloating occurred in 5 patients, transient leukocytosis in 1 patient, abnormal hemoglobin and platelets, and no other complication occurred. One patient At 24 months after radiotherapy, PSA increased from a minimum of 0.056 ng / m L to 6 ng / m L, but no signs of local recurrence and distant metastasis were observed. Five bicalutamide and leuprorelin were recovered After the month, the PSA dropped to 1.539 ng / m L. The other 13 patients without biochemical indicators of rebound and clinical local recurrence. Conclusion After radical prostatectomy at high risk, early adjuvant radiotherapy combined with endocrine therapy can improve local control and short-term survival.