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目的:观察小儿金宁的解热、镇痛、抗炎作用。方法:采用内毒素、干酵母致热法观察其解热作用;采用扭体法、热板法观察其镇痛作用;采用二甲苯致小鼠耳肿胀法和醋酸致小鼠腹腔毛细血管通透性增高法观察其抗炎作用。结果:小儿金宁(4.1、8.2、16.4g/kg)可显著抑制内毒素所致发热反应,小儿金宁(6.85、13.7、27.4g/kg)可显著抑制干酵母所致发热反应;小儿金宁(13.7、27.4、54.8g/kg)对醋酸和热板诱发的小鼠疼痛有明显的抑制作用,可减轻二甲苯所致小鼠耳肿胀度,降低醋酸引起的小鼠腹腔毛细血管通透性增高。结论:小儿金宁具有明显的解热、镇痛和抗炎作用。
Objective: To observe the antipyretic, analgesic and anti-inflammatory effects of Jinling in children. Methods: The antipyretic effect was observed by endotoxin and dry yeast heating method. The analgesic effect was observed by the writhing method and hot plate method. The mouse ear edema induced by xylene and acetic acid induced peritoneal capillary permeability Increased sexual law to observe its anti-inflammatory effect. Results: Jinning (4.1, 8.2, 16.4 g / kg) could significantly inhibit the endotoxin-induced fever response. Jinling (6.85, 13.7 and 27.4 g / kg) could significantly inhibit the fever caused by dry yeast. Ning (13.7,27.4,54.8 g / kg) significantly inhibited the pain induced by acetic acid and hot plate in mice, relieved ear swelling in mice induced by xylene and decreased peritoneal capillary permeability in mice induced by acetic acid Sex increased. Conclusion: Jinning has obvious antipyretic, analgesic and anti-inflammatory effects.