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通过测量 HPMC和 Carbopol974 P在不同 p H值的缓冲液中的混合溶液浊度变化的方法证实了互聚物复合形成。复合的程度在酸性 p H条件下高 ,当两者比例为 1∶ 1时最强 ,然后随着 p H值的升高而减弱。以非洛地平为模型药物 ,采用直接压片工艺制备了口腔粘膜粘附片。体外释放实验表明 ,互聚物复合形成对药物的释放有很大影响 ,能够有效控制药物释放。粘附片中加入不同酸碱度的物质可调节药物的释放速率。聚合物间的这种特殊的互聚物复合形成现象可用于设计具有不同释药行为的药物释放系统。
Interpolymer complex formation was confirmed by measuring the turbidity changes of the mixed solutions of HPMC and Carbopol 974 P in buffers with different pH values. The degree of recombination is high under acidic p H, strongest when the ratio is 1: 1, and then decreases as p H increases. Taking felodipine as model drug, the oral mucosa adhesive sheet was prepared by direct compression. In vitro release experiments showed that the intermolecular compound formation has a great impact on drug release, which can effectively control drug release. Adhesive tablets with different pH substances can regulate the drug release rate. This particular interpolymer complex formation between polymers can be used to design drug delivery systems with different drug release behaviors.