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[目的]分析大肠息肉癌变的相关因素。[方法]回顾性分析2005年3月~2008年3月有病理证实的大肠息肉627例,共872个息肉,对年龄、单发与多发、大小、形态、病理组织类型与癌变的关系进行比较分析。[结果]年龄、息肉大小及病理为腺瘤的癌变率与同组比较差异均有统计学意义。管状腺瘤、管状-绒毛状腺瘤及绒毛状腺瘤的恶变率分别是1.27%、9.64%、32.65%,3组间差异有统计学意义。多发息肉的患者较癌变率较单发息肉者高(7.06%vs 2.23%),但两组息肉数与癌变率的比较则差异无统计学意义。(3.70%vs 2.23%),4组不同形态息肉(平坦,无蒂隆起,亚蒂,有蒂)的癌变率差异无统计学意义。[结论]患者的年龄、息肉大小、腺瘤性伴绒毛状病理表现是大肠息肉癌变的主要相关因素。息肉数目不是其癌变相关因素,息肉的形态学与癌变无统计学相关。
[Objective] To analyze the related factors of carcinogenesis of colorectal polyps. [Methods] A retrospective analysis of 627 cases of pathologically confirmed colorectal polyps between March 2005 and March 2008 with a total of 872 polyps was performed to compare the relationship between age, single and multiple, size, shape, histological type and carcinogenesis analysis. [Results] The age, polyp size and pathological adenoma were significantly different from those in the same group. The malignant rates of tubular adenoma, tubular-villous adenoma and villous adenoma were 1.27%, 9.64% and 32.65%, respectively. The differences among the three groups were statistically significant. Patients with multiple polyps had higher rates of canceration than those with single polyps (7.06% vs 2.23%), but there was no significant difference between the two groups in the number of polyps and the rate of canceration. (3.70% vs 2.23%). There was no significant difference in the canceration rate between the 4 groups of different forms of polyps (flat, non-pedunculated, pedunculated, pedunculated). [Conclusion] The age, polyp size and adenomatous villous pathology of the patients are the main correlative factors of carcinogenesis of colorectal polyps. The number of polyps is not related to its cancer, polyp morphology and cancer were not statistically significant.