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目的:探讨母体与脐血清白介素-17(interleukin-17 IL-17)与妊娠期糖尿病发病(gestational diabetes mellitus GDM)及新生儿出生体重相关性。方法:收集我院足月GDM患者26例为病例组,孕24-28周经50g葡萄糖筛查试验无异常者26例为对照组,分娩前收集两组母血清及脐血清,检测母血清空腹血糖及空腹胰岛素,稳态模型评估胰岛素抵抗(homeostasis model assessment insulin resistance HOMA-IR)。检测两组母血清及脐血清IL-17水平,探讨与妊娠期糖尿病发病及新生儿出生体重相关性。结果:GDM组空腹胰岛素、HOMA-IR、母血清IL-17、脐血清IL-17与对照相比具有统计学差异(P<0.05)。相关研究发现,母血清IL-17水平与HOMA-IR存在明显正相关(r=0.718,P<0.001),脐血清IL-17与新生儿体重存在相关性(r=0.686 P<0.001),但脐血清IL-17水平与母血清IL-17水平无相关性(r=-0.339,P=0.0899)。结论:IL-17可能通过胰岛素抵抗参与了GDM的发生。
Objective: To investigate the relationship between maternal and umbilical serum interleukin-17 (IL-17) and gestational diabetes mellitus (GDM) and neonatal birth weight. Methods: Twenty-six patients with full-term GDM in our hospital were enrolled in this study. Twenty-six of 26 pregnant women with no abnormalities in 50g glucose screening test at 24-28 weeks of gestation were selected as control group. Maternal serum and umbilical serum were collected before delivery, Blood glucose and fasting insulin, homeostasis model assessment insulin resistance (HOMA-IR). The levels of IL-17 in serum and umbilical serum of two groups were detected, and their correlations with the incidence of gestational diabetes and birth weight were explored. Results: The levels of fasting insulin, HOMA-IR, serum IL-17, IL-17 in umbilical serum in GDM group were significantly different from those in control group (P <0.05). Related studies found that there was a significant positive correlation between serum IL-17 level and HOMA-IR (r = 0.718, P <0.001), while there was a correlation between cord serum IL-17 and neonatal body weight (r = 0.686 P <0.001) Umbilical serum IL-17 levels and maternal serum IL-17 levels had no correlation (r = -0.339, P = 0.0899). Conclusion: IL-17 may be involved in the pathogenesis of GDM through insulin resistance.